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Ceftriaxone is indicated in the treatment of
the following infections in adults and children including term neonates (from
birth):
· Bacterial
Meningitis
· Community
acquired pneumonia
· Acute
otitis media
· Intra-abdominal
infections
· Urinary
tract infections
· Infections
of joint and bones
· Skin
and soft tissue infections
· Gonorrhoea,
Syphilis
· Bacterial
endocarditis
· For
treatment of acute exacerbations of chronic obstructive pulmonary disease in
adults
· For
treatment of disseminated Lyme borreliosis (early (stage II) and late (stage
III)) in
adults
and children including neonates from 15 days of age.
· Pre-operative
prophylaxis of surgical site infections
Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic used to treat a variety of bacterial infections in adults and children, including newborns. It is effective against conditions such as bacterial meningitis, pneumonia, urinary tract infections, skin and soft tissue infections, and sexually transmitted diseases like gonorrhoea and syphilis. It is also used in treating bone and joint infections, intra-abdominal infections, and for preventing infections during surgery. Ceftriaxone is commonly administered via injection and is known for its convenient once-daily dosing.
Each vial contains:
Sterile Ceftriaxone Sodium
USP
Eq. to Ceftriaxone anhydrous ………….. 1g
Intramuscular administration/ Intravenous administration
DOSAGE
As directed by the physician.
• Pain,
Induration, Tenderness at the site of infection (1%) less frequently phlebitis
was seen
after IV doses.
• Rash, Pruritus, Fever, Chills
• Eosinophilia, Thrombocytosis, Leukopenia, Anaemeia, Neutropenia,
Lymphopenia,
Thrombocytopenia
• Diarrhoea, Nausea, vomiting, Diageusia
• Headache, dizziness
• Moniliasis/vaginitis
In renal failure no adjustment may be
necessary but serum level should be monitored periodically and the dosage
reduced if required. Dosage adjustment is similarly not essential in hepatic
failure but in patients with hepatic and significant renal malfunction.
Lavincef doses should not exceed 2 g/day without close serum monitoring.
Rarely, alterations in prothrombin time have occurred and may require
coadministration of vitamin K (10 mg weekly). Prolonged use may cause
overgrowth of non-susceptible organism and cause hyper infection. Administer
with caution to patients with history of G.I. diseases, especially, colitis.
50 glass vials of 10 ml packed in a carton along with pack insert