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ARTESUNATE FOR INJECTION 30 MG, 60 MG & 120 MG
Artesunate for Injection administered intravenously or intramuscularly, is indicated for the treatment of severe malaria caused by Plasmodium falciparum, in adults and children.
Each combi pack contains: One vial of Artesunate for injection 120 mg Each vial contains Artesunate 120 mg One 2ml Ampoule of sodium bicarbonate injection BP 5.0%w/v Each ml contains: Sodium Bicarbonate BP 5.0%w/v Water for injection BP q.s One 10 ml ampoule of sodium chloride injection BP 0.9%w/v Each ml contains: Sodium chloride BP 0.9%w/v Water for injection BP q.s. | Each combi pack contains: One vial of Artesunate for injection 30 mg Each vial contains Artesunate 30 mg One 1ml Ampoule of sodium bicarbonate injection BP 5.0%w/v Each ml contains: Sodium Bicarbonate BP 5.0%w/v Water for injection BP q.s One 5 ml ampoule of sodium chloride injection BP 0.9%w/v Each ml contains: Sodium chloride BP 0.9%w/v Water for injection BP q.s. | Each combi pack contains: One vial of Artesunate for injection 60 mg Each vial contains Artesunate 60 mg One 1ml Ampoule of sodium bicarbonate injection BP 5.0%w/v Each ml contains: Sodium Bicarbonate BP 5.0%w/v Water for injection BP q.s One 5 ml ampoule of sodium chloride injection BP 0.9%w/v Each ml contains: Sodium chloride BP 0.9%w/v Water for injection BP q.s. |
Method of administration: I.V / I.M Powder for Injection
DOSAGE FOR ADULTS
The recommended dosage of Artesunate for Injection is 2.4 mg/kg administered intravenously at 0 hours, 12 hours, and 24 hours, and thereafter, administered once daily until the patient is able to tolerate oral antimalarial therapy.
Administer constituted Artesunate for Injection intravenously as a slow bolus over 1 minute to 2 minutes [see Preparation of Artesunate For Injection For Intravenous Administration]. Do NOT administer Artesunate for Injection via continuous intravenous infusion.
Administer Artesunate for Injection with an antimalarial agent that is active against the hypnozoite liver stage forms of Plasmodium, such as an 8-aminoquinoline drug, to patients with severe malaria due to P. vivax or P. ovale.
More common minor side effects associated with IV administration have included dizziness, light-headedness, rash, and taste alteration (metallic/ bitter taste). Nausea, vomiting, anorexia and diarrhea have also been reported, however it is uncertain whether such events have been symptoms of severe malaria.
Artesunate has not been evaluated in the treatment of severe malaria due to Plasmodium vivax, Plasmodium malariae or Plasmodium ovale.
Acute treatment of severe falciparum malaria with Artesunate for Injection should always be followed by a complete treatment course of an appropriate oral combination antimalarial regimen.
Artesunate for Injection is available in a vial + 1ml Ampoule of sodium bicarbonate injection + 5 ml ampoule of sodium chloride injection.